cyto.site

erythrocyte

erythro.site · being built

What it isThe red blood cell, a biconcave disc without a nucleus that carries oxygen and carbon dioxide between the lungs and the tissues.
Comes fromHematopoietic stem cell
AboutEnucleation, the process by which the nucleus is extruded by budding off from the erythroblast, is unique to mammals and gives red cells their flexible biconcave shape.
SourceJi P, Murata-Hori M, Lodish HF. Formation of mammalian erythrocytes: chromatin condensation and enucleation. Trends Cell Biol. 2011;21(7):409-15. PMID: 21592797
Statusbeing built; its twin, knowledge and helper come with erythro.site

Where it lives

In the blood, deforming to pass capillaries smaller than its diameterhuman · PMID 25332724
Through the spleen's red pulp, where narrow interendothelial slits retain the cells that cannot deformhuman · PMID 21163923

What it does

Lives about 106 days, plus or minus 21, in a hematologically normal personhuman · PMID 25293624
Is removed by the spleen when oldhuman and mouse · PMID 16056254

What goes wrong

In sickle-cell disease haemoglobin polymerisation makes the cell rigid and occludes the vesselshuman · PMID 21131035

cytology · hub