cementocyte
cemento.site · being built
| What it is | The cell embedded in the cellular cementum of the tooth root, a cementoblast that was buried in the matrix it made. |
|---|---|
| Comes from | Neural crest cell |
| About | During formation of the apically located cellular cementum some cementoblasts become embedded in the cementoid matrix and become cementocytes, apparently terminally differentiated cells in a mineralised matrix, the osteocyte's closest relative. |
| Source | Zhao N, Foster BL, Bonewald LF. The Cementocyte-An Osteocyte Relative? J Dent Res. 2016;95(7):734-41. PMID: 27029548 |
| Status | being built; its twin, knowledge and helper come with cemento.site |
Where it lives
| In lacunae within the cellular cementum of the apical root, canaliculi running through the matrix | human · PMID 9631176 |
| Cementocyte lacunae with canaliculi lie in the apical region of the root, DMP1 on their walls | monkey · PMID 22435407 |
What it does
| Keeps a lacuno-canalicular system whose function, like the osteocyte's, is an open question | human and mouse · PMID 27029548 |
| Forms during a cementogenesis that lasts 5 to 7 years in a human premolar | human · PMID 8769668 |
What goes wrong
| In GACI with ENPP1 loss the cementum expands 5-fold with cementocyte-like cells | human and mouse · PMID 29244957 |
| In periodontal disease the lacunar lining keeps its proteoglycans while the attachment above is lost | human · PMID 10207837 |